Sentence examples for of many signalling pathways from inspiring English sources

The development of the Drosophila compound eye is a complex process involving the interplay of many signalling pathways (reviewed in [1]).

MyD88 is at the crossroads of many signalling pathways involving TLR receptors and the IL1R, and a common end result is NF-κB driven induction of inflammatory cytokines and chemokines, resulting in inflammation.

These findings also emphasise the interconnected nature of many signalling pathways in breast cancer: crosstalk between Wnt and EGFR signalling is one example, but another example currently under intense investigation is the emerging link between steroid receptor and receptor tyrosine kinase signalling.

MCM proteins stand at the end of many signalling pathways involved in cell proliferation [ 23].

Such ultrasensitivity, as characterised by a sigmoid signal/response curve, is an important feature of many signalling pathways and cellular decision making processes.

P62 is indeed at the crossroads of many signalling pathways involved in controlling autophagy, tumorigenesis and the cell death/survival balance (Moscat and Diaz-Meco, 2009).

Moreover, systematic analyses of many signaling pathways revealed a general oscillation pattern of activation/inactivation signaling dynamics (Purvis et al., 2012; Purvis and Lahav, 2012, 2013).

Indeed, these small domains are involved in the regulation of many signaling pathways and possess structural properties which are favorable for the design of competing ligands.

It has been known that the development and the progression of pancreatic cancer are caused by the activation of oncogenes, the inactivation of tumor suppressor genes, and the deregulation of many signaling pathways among which the EGFR, Akt, and NF-κB pathways appear to be most relevant.

These diverse results highlight the broad role that mTOR has as a downstream effector of many signaling pathways.

Indeed, each of these components of the ATX LPA signaling axis sufficiently induces tumorigenesis through the upregulation of many signaling pathways, including signaling pathways via PI3K, MAPK, Wnt/β-catenin and estrogen receptor [7], [10], [11].