Sentence examples for of major signalling pathways from inspiring English sources
Inhibition of major signalling pathways and microtubule polymerization.
A number of major signalling pathways lie genetically downstream of Pax3.
It was noted that hsa-miR-181a/b overexpression coincided with aberrant activation of major signalling pathways involved in breast tumourigenesis, including IL6/STAT3 [ 43], TGF-β [ 44, 45], HIF-1 [ 46], WNT/β-catenin [ 47] and HMGA1 [ 48].
23 27 mTOR is located at the intersection of major signalling pathways and is believed to be capable of integrating a large panel of stress signals, including nutrient deprivation, energy depletion, and oxidative or hypoxic stresses.
The differential expression of the 204 gene set when the two groups were compared provides experimental evidence of major signalling pathways leading to difference in PFS associated with the development of the chemotherapy resistant phenotype.
Collectively, these findings suggest that the enhanced antitumour activity of sorafenib in ACHN cells by combining with OGX-011 could be explained by, at least in part, the direct inhibition of their proliferation through the inactivation of major signalling pathways in addition to the modulation of apoptosis-related proteins.
Importantly, our findings establish a role for U6atac in regulation of major signaling pathways.
Conservation of major signaling pathways between humans and flies has made Drosophila a useful model organism for cancer research.
These factors activate the transcription of their own genes and genes of major signaling pathways, but repress the transcription of some developmental genes [ 31].
To determine the signaling pathways responsible for PTK6 downregulation-mediated Bim induction in UACC893R1 and MDA-MB-453 cells, we examined the status of major signaling pathways activated downstream of Her2 that have been implicated in survival, and Bim regulation [ 26, 28].
Orthologs of at least 16 transcription factors and 7 members of major signaling pathways are present as candidates of potentially general function, and orthologs of 2 apoptosis-related and 2 actin-associated genes may represent functional candidates that are involved in the specific downstream processes that determine worker ovary size [ 39].
