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But when treatment begins early, as has happened in Mr. Bush's case, the chances of maintaining vision are good, ophthalmologists say.
It is noteworthy that this level of maintaining vision was also achieved for the subgroup of patients with VA ≥20/40.
A pivotal study comparing RETAANE suspension with placebo showed a significantly higher chance of maintaining vision in the treatment (73%) as compared with placebo (47%).
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The efficacy of anecortave acetate 15 mg for maintaining vision and suppressing lesion growth in patients with exudative AMD have been confirmed by long-term study results.
The primary endpoint analysis was non-inferiority of IVT-AFL to ranibizumab in the proportion of patients maintaining vision at week 52 (losing <15 Early Treatment of Diabetic Retinopathy Study ETDRSS) letters, in the perprotocol set (PPS)), described in the primary publication.
The four groups had comparable primary endpoint, that is, the proportion of patients maintaining vision (defined as losing <15 letters on an ETDRS chart) at 52 weeks.
Ninety per cent of all eyes treated with ranibizumab at 0.5 mg lost less than 15 letters compared with 66% of eyes maintaining vision with PDT treatment alone at 24 months.
Long-term follow-up may help to establish the utility of intravitreal bevacizumab for diabetic macular edema, as well as determine the regimen of treatment to maintain vision and prevent recurrence.
The objective of this study will be to investigate whether RETAANE 15 mg (anecortave acetate suspension) reduces the frequency of intravitreal injections while maintaining vision and limiting disease progression in patients who are receiving intravitreal injections of bevacizumab (Avastin) for treatment of exudative AMD.
Our group has previously shown that if ranibizumab therapy is initiated in eyes with good visual acuities, the treated eye is more likely to maintain good vision, 8 and this is consistent with the indirect evidence from the pivotal trials that eyes are more likely to maintain vision than recover lost vision at initiation of treatment.
In the anecortave acetate group, 73% of patients maintained vision compared with 47% in the sham group.
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