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At the time of its initial diagnosis, bladder cancers tend to be of lower stage (Larsson et al, 2003).
The remaining 28% of the patients had tumors of lower stage that did not require multimodal treatment after final pathological examination [ 19].
Stage T1 and high-grade tumors had generally more unstable genomes than tumors of lower stage and grade (mostly non-primary tumors following a "high-risk" tumor).
When this latter pattern is prominent, tumours tend to be of lower stage, show less vascular invasion (see below), and patients survive for longer [40 42].
If most tumours with unknown stage tumours are indeed of lower stage, the percentage of lower stage (stage 0, 1 or 2) would be around 90%, being somewhat higher than that in other studies (McDonald, 1982; Roush et al, 1985; Wright et al, 2008).
Tumours from familial non- BRCA1/ BRCA2 patients were similar to sporadic ones, although they were of lower stage and CK-14 was expressed more often than among sporadic tumours (Table 2).
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The experimentally observed induced reverse gas flow is accounted for by a recycle stream from any one cell being distributed over a number of lower stages.
In view of the growing importance of lower stages of CKD, setting up of CKD Registries has also been advocated [ 23].
Using northern-blot analysis, consistent GATA-2, -3 and FOG-2 expressions were observed in tumours of lower stages (n=11), whereas a remarkable reduction in mRNA levels of all three genes was found in neuroblastoma of stage 4 (n=3; Supplementary figure S1).
In patients from the surveillance group, the observed number of lower-stage tumours was higher than the expected number.
In addition, B2 with or without serum produced embryos of a lower stage of development, lower quality and fewer cells than did B2 BRL coculture.
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