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In particular, why has there been such a serious resurgence in Angola and the DRC, stretching vaccine supplies to the point that consideration is being given to reducing the dose in order to cover more people – or even to offering doses of lower efficacy to larger numbers of individuals in an effort to halt transmission through an overall increase in protection?
Nevertheless, more research is needed to explore the generalizability of the findings to vaccines of lower efficacy.
Galangin is a partial agonist of lower efficacy than PCB105 [see Supplemental Material, Table 3, (doi 10.1289/ehp.0901312), for means ± SEs].
6 7 Furthermore, emergence of resistant strains will certainly be higher in these patients because of lower efficacy of SOC and greater need for dose adjustments.
The tendency of lower efficacy with femoral block may be due to the fact that the posterior part of the knee is innervated by the sciatic nerve.
Another potential explanation for the negative results is that, because of lower efficacy, ibuprofen may require more sustained treatment, as was done in the APP transgenic mouse line.
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7 The potential reasons for lower efficacy of aspirin in people with diabetes compared with other high risk populations have been explored.
However, a randomised trial failed to show any favourable effect of higher than 175 mg m−2 of paclitaxel every 3 weeks in ABC, which excludes such an explanation of the lower efficacy of paclitaxel when compared to EoP in our trial (Winer et al, 2004).
Therefore, the intention to reduce hypotony risk by using a lower laser power and fewer applications per treatment should be weighed against the possibility of a lower efficacy of the cyclodiode treatment.
The effects of reduction of AAAS expression are less remarkable in the SH-SY5Y cells, and this could be a feature of the lower efficacy of the knockdown in this cell line.
She chose to use the progesterone-only pill and struggles with the uncertainty of its lower efficacy rate.
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