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In addition to reducing spending on expensive drugs, the proposals will also seek to reduce spending on drugs that are of lower effectiveness.
However, given the wide confidence limits, caution is warranted in interpreting findings of lower effectiveness among older children.
Only one study (reference number 10) applied sensitivity analyses applying changes in three different scenarios, namely lower estimate of effectiveness, full costs of implementation and worst-case scenario, i.e. combination of lower effectiveness and full cost.
Given that the Alli dosage is only half of the prescription-strength orlistat dosage (60 mg vs 120 mg), its cost-effectiveness may be less favorable because of lower effectiveness.
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These alterations can lead to lower effectiveness of some drugs, such as enalapril, which is a pro-drug, and its bioavailability can be affected by reduction of the first-step metabolism [ 7].
Similarly, in the rigorous contact reduction scenario the effect of delayed response on attack rate was more pronounced in the Albany model, due to lower effectiveness of interventions in a PNG setting.
While testing the hypothesis of a lower effectiveness of DMARDs and biologic agents in observational studies compared with clinical trials, we found that new drugs may have an impact – benefiting not only patients who are exposed to them, but also the nonexposed patients.
The frequency of side effects, lower effectiveness in chronic infections, and logistical difficulty for physicians wishing to prescribe these drugs create barriers to successful treatment of patients with Chagas disease.
Hand pollination resulted in more fruit set than natural pollination and this confirm that there is pollination deficit in this species and is mainly attributed to the lack of pollinators or lower effectiveness of the pollinators.
Mr. Graedon and the lab conjecture that the different dissolution rates might be to blame for the reported side effects and lower effectiveness of Budeprion.
In our opinion this difference, however, reflects the small number of animals in each experimental group, which reduced the statistical power of the analysis, and the lower effectiveness of minocycline in sensitizing PrP peptides to protease hydrolysis, as shown in cell-free tests [7].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com