This behavior places a restriction on functional space that can be explored and is not consistent with observations from nature, where sequences of low identity have similar structures.
Moreover, the performance gain is maximized when the two compared sequences are of low identity, because the number of the candidates for seed-inserting positions is limited.
In spite of low identity between bacterial and mammalian SMases, the amino acid sequences share a number of conserved residues, suggesting a common catalytic mechanism [28], [29].
Evaluation of emergence on evolutionary timescales, as well as estimation of horizontal gene transfer (HGT) extent prompted by this distribution remain both problematic because of low identity levels among transposases.
We show that sequence embedding could serve as one of the vehicles for measurement of low-identity alignments and for incorporation thereof into high-performance PSSM-based alignment profiles.
We finally developed a pig SD database based on the union of low-identity WGAC (<94%), filtered high-identity WGAC (≥94%) and the WSSD estimates.
By using up to three mismatches when mapping to consensus TE sequences, a substantial portion of low-identity TE sequences may be missed.
Most of the amplified marine sequences of this study exhibited low identities with known WS/DGAT enzymes and showed no close relatives, suggesting the phylogenetic diversity and novelty of these genes.
The nucleotide and amino acid VP1 sequences of 4 FDJS03 isolates showed low identities with the HEV-A, HEV-C, and HEV-D enterovirus species.
All of these duplicate genes show low identities to each other (20% and 6%).
