Consistently the proteomic analysis shed light on large modification of enzymes involved in the transport and catabolism of metabolites necessary for energy production.
This suggests that further mechanisms most likely contribute to the differences in observed identification rates such as general differences in fragmentation patterns due to changes in chemical properties induced by derivatization and possibly also an inherent effect of large modifications on search engine algorithm scoring processes.
The notion of hypersensitivity is illustrated: a weak geometrical modification, a defect in connexion angle, can under certain conditions lead to large modifications of the vibrational behaviour.
Considering the linear structure of the LARGE modification, its incorporation of GlcA, and the fact that it is synthesized by a polymerizing enzyme that possesses dual glycosyltransferase activities, this novel polysaccharide may fit into the category of GAGs.
Examination of the modification index revealed the presence of 18 large modification indices (>10).
Although structural changes in [Mn6]2+ as a cause of the large modification in the relaxation dynamics certainly cannot be ruled out, it seems likely that the role of the [ReIVCl6]2− anion is non-innocent.
The other consists of the changes brought about by mutations, spontaneous alterations of genes that result in large modifications of the organism and give rise to new species: "The new species thus originates suddenly, it is produced by the existing one without any visible preparation and without transition".
This was well demonstrated by the model, where the large CaMK facilitation could be expected to produce a large modification of E-C coupling, but in silico the effect turned out to be rather small.
Native LARGE modification of α-DG is regulated directly and/or indirectly by the activities of a number of other enzymes, including HNK-1ST, B3GNT1, and possibly SLC35A1 and POMGNT1 (see below).
Cold acclimation is associated with large modifications of gene expression [ 3- 6].
These changes consisted of correlating variables with very large modification indexes.
