Exact(6)
Well organized and easily accessible databases permit the easy retrieval and analysis of large interaction data sets.
However, such coupling becomes ineffective in the regime of large interaction strengths on which the energy bands corresponding to these two classes of eigenstates become quite detached.
One of the major challenges in systems biology is to combine in a meaningful way the large corpus of molecular biology knowledge recapitulated in the form of large interaction networks together with high-throughput omics data [ 1].
For two prominent case mix variables the Charlson index of comorbidity and emergency admission we did detective work to seek explanations for the presence of large interaction effects, as described below.
We first tested for the presence of large interaction effects and then, in respect of two key case mix variables (comorbidity index and emergency admission), we did detective work to seek likely explanations.
Main outcome measures Presence of large interaction effects between case mix variable and hospital in a logistic regression model indicating non-constant risk relations, and plausible mechanisms that could give rise to these effects.
Similar(54)
In the next section we will calculate the low-lying energy eigenstates exactly analytically in the limit of large interactions in the thermodynamic limit.
For minimisation, which does not balance within strata, either a stratified or a covariate adjusted analysis will give valid type I error rates in the presence of large interactions.
Nonetheless, our secondary analyses will evaluate the possibility of a main effect, both in isolation and as part of larger interaction models (cf. models S1A1 and S1B1 above) for completeness.
The primary outcome of this study was the absence of a large interaction between digoxin use and sex affecting mortality.
Most of the large interaction databases include data for many different species.
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