Exact(50)
In these plots, the intensity of each observed lactone was normalized to the most abundant lactone and plotted as a function of percent lactonization (number of lactones divided by the DP).
In contrast, the glycans with a large number of lactones (more than 2) had lactonization peaking at ∼80%.
Interestingly, we observed significant "heavily" sialylated glycans containing a low level of lactones (1 2 lactones), as indicated in Figure 6 showing 20% lactonized at this level.
Using the new reactivity of the ketoreductase, the authors carry out enantioselective dehalogenation of lactones by irradiation with visible light, a challenging transformation by traditional small-molecule catalysis.
Not surprisingly, enzymes involved in the bioprocessing of lactones are often targeted for protein engineering studies with the potential, for example, of optimized bioremediation of aromatic pollutants.
Biodegradable polyesters and corresponding nanoparticles have been synthesized by an "eco-friendly" technique; enzyme-catalyzed ring-opening polymerization of lactones in bulk and in an aqueous mini-emulsion.
Similar(10)
The percent lactonization can be calculated by dividing the number of lactone groups by the total number of sialic acids residues in the composition.
The partially silylated dextrans were efficiently used as multifunctional macroinitiators for the controlled ring-opening polymerization (ROP) of lactone.
hotoexcitation of a catalytic enzyme enzyme's co-factor is shown to change the reactivity of the enzyme, enabling it to carry out a non-natural enantioselective dehalogenation of lactone molecules.
According to the estimation, the fraction of lactone increases with decreasing pH, finally to ca. 65 mol% at pH 1. Ab initio calculation of the lactone ring formation energy supported the i.r.r
This is the first successful design of lactone-free CPT, providing thus a new avenue to the development of topoisomerase I targeted antitumor agents.
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