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Unexpectedly high rates of ITS variability have been reported in samples collected from the same patient at different times during a single disease episode (36 ).
The lack of ITS variability of W. anomalus strains could be explained by the small number of sequenced isolates (n = 6), by possible clonal origin or even by a low mutation rate of the gene selected in our present study.
Analysis of ITS variability revealed a greater number of haplotypes among C. albicans, C. tropicalis, C. glabrata and C. lusitaniae, which are predominantly related to endogenous sources of acquisition.
Thus, given the poorly defined boundaries of some genera and lack of ITS variability in several species, classifying an unknown ITS sequence to species, and sometimes genus rank will not always produce a definitive answer.
The inability to pass on variability is an attribute of a replicator that can have variability (acquired or generated), but it cannot pass on any of its variability to the next generation.
Basically, for a profile with a lower standardized partial variance, much of its variability is explained by the profiles connected to it, while for a profile with a high standardized partial variance, less of its variability is explained by the profiles associated to it.
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The presence of intraspecific ITS variability was characterized based on haplotype networks, and Bayesian analysis was used to develop phylogenetic inferences.
However, a model-based characterization of the pharmacodynamics (PD) of 4βHC, and its variability, in humans will provide a thorough understanding of its dynamic properties as a biomarker.
"There's certainly the desire to have natural light because of its temperature, its variability and the sense of access to the outside," he said.
For instance, Δ = 0.5 may represent that every reaction in the system looses 50% of its reference variability, that 50% of the reactions in the system loose all their variability or any intermediate situation.
Sample size estimation is one approach since it reflects the size of the biologic or clinical effect of interest and its variability (subsuming both biologic and measurement variability).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com