Sentence examples for of its translocation from inspiring English sources

There has been no direct observation of p53 moving along DNA, however, and little is known about the mechanism and rate of its translocation.

A novel, phosphotyrosine-independent binding interaction between BCR, the Philadelphia chromosome breakpoint cluster region gene product, and the SH2 domain of its translocation partner c-ABL has recently been reported.

In this study we have investigated the structural characteristics of GSTM2 that govern the efficiency of its translocation into L929 cells.

The strength of an antibiotic interaction with the affinity site of a channel greatly influences the efficacy of its translocation [31], [32].

PapC usher organization and detail of its translocation domain.

22Rv1 cells responding to sorafenib demonstrated cleaved Bax, activation of caspases, cleavage of PARP and processing of AIF, characteristic of its translocation to the cytoplasm.

NPM1 mutations are characterised by four basepair insertions within the region corresponding to the C-terminus of the protein leading to its translocation out of the nucleus.

Phosphorylation of HOG1 leads to its translocation into nucleus and activation of the genes responsible for osmotic-stress regulation (Fassler and West 2010; Gao and Stock 2009).

Concerted rephosphorylation of NFATc leads to its translocation into cytosol and abrogation of NFATc transcriptional activity [ 18, 19].

For example, AAH hydroxylation of Notch leading to its translocation to the nucleus reflects post-translational regulation of Notch protein.

The mitochondrial oxidative and nitrosative stress induced by NAPQI protein binding then initiates a cascade of amplifying events, which include activation of JNK, its translocation to the mitochondria and ultimately, initiation of the mitochondrial permeability transition (MPT).