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Third, the above-mentioned negative feedback loop, in which SRSF1 promotes an increase in unproductive splice variants of its own transcripts, can be subverted in the presence of splicing regulator SAM68.
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Notably, AtGRP7 itself influences the oscillations of its own transcript at the post-transcriptional level [ 20, 21].
The clock-controlled RNA-binding protein AtGRP7 influences circadian oscillations of its own transcript at the post-transcriptional level.
Nothing is presently known about the mechanism through which the tephritid Tra protein controls the splicing of its own transcript.
While this manuscript was in preparation Lund et al reported of an effect of Npl3 in autoregulation of its own transcript [32].
Similarly, PABPC1 is involved in the translational repression of its own transcript by binding an adenine-rich autoregulatory sequence (ARS) in the 5'-untranslated region [43].
The respective gene product in turn is able to dampen expression of its own transcript by interaction with the white collar complex [ 124].
FY physically interacts with the plant-specific, RNA-binding-motif protein FCA; this interaction is required for a negative autoregulatory mechanism controlling FCA protein accumulation, where full-length FCA protein promotes premature cleavage and polyadenylation of its own transcript [ 70].
TDP-43 strictly regulates its messenger RNA levels by directly binding to an intron in the 3′-untranslated region of its own transcript and enhancing its splicing (Ayala et al., 2010; Polymenidou et al., 2011), however, the expression level of TDP-43 can be upregulated ∼1.5-fold (Mishra et al., 2007; Gitcho et al., 2009) in FTLD/ALS.
The binding of FUS to its own transcript suggests an autoregulatory mechanism for FUS expression (Lagier-Tourenne et al., 2012; Nakaya et al., 2013) that may be relevant to ALS pathogenesis.
Note that in Figures 8A and 8B, read counts when mapping a species' reads against its own transcripts showed a pattern of truncation on the lower end.
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