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We focused on two proteins: huntingtin, because of its centrality to HD, and lactate dehydrogenase (LDH), because of its documented sensitivity to copper, necessity for normoxic brain energy metabolism and evidence for altered lactate metabolism in HD brain.
We focused on two proteins: huntingtin, because of its centrality to HD [32], and lactate dehydrogenase (LDH) because of its documented sensitivity to copper [15], necessity for normoxic brain energy metabolism [18] and evidence for altered lactate metabolism in HD brain [19].
GSNO is a NO-releasing agent with properties comparable to spermine/NO or SNAP [75], and was chosen as an NO donor because of its documented ability to up-regulate expression of hmp [76] [78] and therefore expression of the Hbs under the control of the hmp promoter on the pANX plasmid.
However, because of its documented general usability in the assessment of depression, we employed this questionnaire [ 30].
We chose Maximum Entropy ("Maxent") [ 66], a statistical mechanics approach, as our modelling algorithm because of its documented success at modelling species with limited locality data, a common problem when working with endemic species [ 65, 67- 69].
β-naphthoflavone, a bifunctional (phase 1 and 2) enzyme inducing compound, was selected because of its documented ability to induce phase 2 enzyme activity in rodent tissues in vivo and for comparison to the other compounds since it increased NQO1 activity to a lesser degree in the prostate cells in vitro [ 15].
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That last part is actually the most interesting aspect of this new site because Google is also publishing a number of its documents about how it does open source internally.
But PwC Luxembourg remains furious at what it calls the "theft" of its documents.
And some of its documents are facsimile or photographic copies.
There was also activity today involving another former Boston clergyman, as a judge here ordered the archdiocese to turn over thousands of its documents on 62 priests.
Under copyright law, the church was obligated to publish some of its documents before 2003 or lose them to public domain.
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