Furthermore, the mechanisms at play may vary depending on the context of inflammation and microenvironment of the involved tissues.
Facial allografts have varied in the composition of the involved tissues, conditioning the extent of the respective surgical procedure.
Out of thirty cases that were treated primarily on presentation, twenty-seven (90%) healed uneventfully with desirable aesthetic effects while three (10%) patients had infections of the wounds with some necrosis of the involved tissues.
Conversely, in the late disease stages, the entire process may evolve to irreversible fibrotic changes of the involved tissues and organs [ 2- 4].
Clinically, nasal NK/T cell lymphoma had unique features characterized by destruction of the nasal cavity and midline facial tissues caused by progressive and unrelenting ulceration and necrosis of the involved tissues, as demonstrated in Fig. 1.
We immunohistochemically studied nasal NK/T-cell lymphoma to elucidate the unique characteristics of nasal NK/T-cell lymphoma, such as its higher metastatic tendency and its vast necrosis which leads to destruction of the involved tissues.
While the debate continues about which of the involved tissues - cartilage, bone or synovium - is the most important in OA aetiology, there is no doubt that the three develop abnormalities in concert; perhaps a truly useful biomarker will reflect just that.
This is presumably because the serum response is reflective of tissue responses in all involved tissues of the upper extremity and body, not just the forearm tissues examined in this study.
These results combined with those by Sommerich et al [ 46] and Freeland et al are suggestive [ 47] of only a transient or even an absent serum cytokine response, dependent on several variables, such as the type of inducing task, the involved tissues, the timing of serum collection, such as before, during or after an acute injury phase or even the age of the individual or animal.
