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This spectrum is mimicked in the mouse models; R133C being least severe, T158M most severe and R306C of intermediate severity.
Genetic studies have widely unraveled the molecular basis of the most severe forms, while cases of intermediate severity are more difficult to characterize, probably because of a large heterogeneity.
There have been several reports about patients showing symptoms of intermediate severity, which ranged between HGPS and RD (Moulson et al., 2007; Youn et al., 2010).
The broad range of phenotypes has led to classification into clinical types including the most common severe infantile form (SMA type I), non-ambulatory variants of intermediate severity (SMA type II), and ambulatory variants (SMA types III, IV).
Acetylcholine induced a positive vasomotor response, which was also associated with a regional perfusion defect in 1 of 3 coronary arteries with stenoses of intermediate severity (50% to 69%).
Each hip was judged to be a stable SCFE of intermediate severity.
Similar(36)
We conclude that the structure and dynamics of the studied primeval forest landscape was driven by the combined impact of small-scale "background" mortality (classical gap dynamics) and infrequent episodes of patchy intermediate severity and scale disturbances.
However, the lack of a normal distribution could reflect an artefact of insufficient numbers of patients with intermediate severity, non-linearity of the BFM scale, more frequent progression of patients with intermediate scores, or recurrent mutations that result in non-random clinical outcomes.
The results from the other two types of learning task showed intermediate severity of impairment in the fornix-transected animals.
We were able to identify patients who seemed to profit more from high frequency of care: those with an intermediate severity of illness.
However, increasing recognition of cases with intermediate severity led to later classification systems that involved three or four groups, based on specific neurobehavioural features.
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CEO of Professional Science Editing for Scientists @ prosciediting.com