Sentence examples for of integrated pathway from inspiring English sources

These results underscore the prediction power of integrated pathway markers (L values) in comparison to standard models based on individual gene profiles, including those derived from highly perturbed pathways.

This highlights the importance of integrated pathway data.

PARADIGM produces a matrix of integrated pathway activities (IPAs) A where A ij represents the inferred activity of entity i in patient sample j.

We have now made use of the unprecedented conjunction of large-scale cancer genomics profiling of tumor samples in The Cancer Genome Atlas (TCGA) and of tumor-derived cell lines in the Cancer Cell Line Encyclopedia, as well as the availability of integrated pathway information systems, such as Pathway Commons, to systematically search for a comprehensive set of such epistatic vulnerabilities.

Eukaryotes have evolved a wide variety of integrated pathways to sense and repair multiple types of DNA damage, from bulky lesions to double strand breaks.

In higher eukaryotes, protein misfolding results in endoplasmatic reticulum (ER) stress and initiates the unfolded protein response (UPR), a cascade of integrated pathways regulating gene expression.

Users can easily get the following statistics: number of genes, number of gene pairs, number of integrated pathways, number of original KEGG pathways, number of original WikiPathways pathways, number of original BioCyc(MouseCyc) pathways, and number of source databases.

However, for the complex inter-relations among the cellular mechanisms involved in breast tumour growth and progression, this information has not always been evaluated as part of integrated pathways.

Additional experiments will be required to elucidate the physiological consequences of activation of the integrated pathway and to determine how or if manipulation of BiP levels might affect the response.

Based on these observations, we considered as components of the integrated pathway only the subset of the co-regulated genes that were synergistically induced by the simultaneous treatment of the soybean plants with AZC and PEG.

Despite the recent availability of several integrated pathway maps, the abstraction level of represented entities in these maps is often not sufficient to map experimental data, which is primarily due to the objectives of each pathway database.