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Patients were included in the following groups: observation if no additional treatment was initiated within 215 days after the completion of initial therapy or R-maintenance if R-maintenance and no additional treatment was initiated within 215 days after the completion of initial therapy.
Logistic regression, adjusted for patient characteristics, was used to model the association between 1) GI events and OP treatment initiation (treated versus nontreated); and 2) GI events and type of initial therapy (BIS versus non-BIS) among treated patients only.
Of note, while some studies showed a delayed administration of systemic antifungal therapy (SAT) was associated with increased mortality [10 12], others did not found any relationship between prognosis and the timing of initial therapy [13, 14].
Treatment should be given either at early stage in case of fulminant sepsis or rapidly after assessing the impact of initial therapy or surgery, but without exceeding 48 hours of evolution.
To evaluate the impact of risk factor-guided selection of initial therapy, we compared the combined incidence of lactic acidosis and hyperlactatemia among treatment-naive patients initiating stavudine-containing therapy with those starting zidovudine-containing therapy.
Sixty (3.5%) patents relapsed following completion of initial therapy.
We also specifically controlled for the timeliness of initial therapy.
The results of initial therapy are presented in Table 3.
The choice of initial therapy varies according to cost and drug availability in various countries.
Aggressive intravenous fluid therapy according to the Baxter formula is a mainstay of initial therapy.
Thus, the epidemiology of candidemia may impact the choice of initial therapy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com