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Important clinical and laboratory variables, such as age, sex, preexisting underlying disease, clinical diagnosis, severity of infectious condition, microbiology of culture from infection source, hematologic data, and chemistry data, were collected when CRP and PCT tests were conducted.
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The high rate of death from pulmonary tuberculosis and pneumonia calls for better management of infectious conditions before they present as BID.
In particular, cultural views of infectious conditions that require antibiotic treatment differ between countries (14).
Social constraints and cultural views of infectious conditions that require antimicrobial treatment exert a strong influence on their use, particularly for community-acquired pathogens.
Another marker of inflammation, C-reactive protein remains widely used throughout the world for diagnosis of infectious conditions - despite its rather limited diagnostic accuracy when used as a single measurement in time [ 41].
Third, the definition of infection used in the present study might have resulted in the collection of cases with a wide range of infectious conditions (i.e., from short-term infectious local findings with good general condition to fatal septic shocks).
There are a variety of chronic inflammatory conditions (where no causal agents have been identified), e.g. Barrett oesophagus, chronic ulcerative colitis, as well as a variety of infectious conditions, such as chronic gastric infection with H. pylori and chronic viral hepatitis, that markedly elevate the risk of cancer.
Moreover, the high presentation of infectious conditions may suggest that the prevalence of communicable diseases in Egypt is still high and that Egypt as many other developing countries is facing a dual burden of disease; a persistently high burden of communicable diseases and a rapidly increasing burden of non-communicable diseases [ 14].
Presence of a diagnostic code in the chart or a clinician diagnosis of an infectious condition does not necessarily signify a true infection (19 ).
Resistance to antibiotics and ability to form biofilms are common findings among mastitis-causing strains and may explain the often recurrent nature of this infectious condition [ 21].
We suggest that both conditions result from an inflammatory disorder as a result of an infectious condition, both crucially linked to sterol metabolism and innate immunity, leading to vascular occlusion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com