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Our data suggest that patterns of incomplete adherence, namely interruptions in treatment, may narrow this window.
These methods, however, also indicated higher levels of incomplete adherence compared to clinic-based measures.
Substance use is also a predictor of incomplete adherence to antiretroviral therapy [6], which in turn may lead to drug resistance [12], [13], as well as to more rapid progression to AIDS and mortality [14] [16].
Here we present secondary analyses to investigate the consequences of incomplete adherence for inferences about the effects of early weaning, comparing outcomes among mother-child pairs in the intervention and control groups who stopped breastfeeding earlier or later than intended by the study design.
This type of bias is common and can lead to under-reporting of incomplete adherence [ 12].
While transient low-level viremia has been associated with transient periods of incomplete adherence [ 23], we were unable to assess such an association in our small pilot study.
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We assessed risk factors for incomplete adherence among a cohort of HIV-infected women initiating ART and examined associations between adherence and virologic response to ART.
In this study, we used <95% as a conservative cut-off point for incomplete adherence.
Here, women, with less education were at higher risk for incomplete adherence.
Nevertheless, therapeutic failure still remains substantial, in particular due to late initiation, interruption or refusal of cART, incomplete adherence to therapy, medication toxicities, antiretroviral drug resistance, hepatitis virus co-infections, consumption of alcohol, illicit drug use, or depression.
No conclusion can be drawn about the effect of nutritional supplementation for this type of patients due to the limited number of participants and incomplete adherence with use of the supplements.
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