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In order to gain insight into the development of human-specific features of the cerebral cortex, we investigated gene expression patterns in cortical domains that contain areas thought to have undergone significant divergence during primate evolution.
Watanabe, M. et al. Self-organized cerebral organoids with human-specific features predict effective drugs to combat Zika virus infection.
The non-conserved sequences might relate to the emergence of human-specific brain features [49].
What makes HAR1A somewhat unique is that it is one of the "highly accelerated regions" [111], where evolutionary mechanisms have created pressure for the emergence of "human-specific" brain features.
"Our system allows us to study human-specific features of brain development".
Before this study, this sensitivity was considered a human-specific feature of cultural learning.
McLean, C. Y. et al. Human-specific loss of regulatory DNA and the evolution of human-specific traits.
Therefore, the genetic diversity seen in this species can be largely attributed to random genetic drift within a rather stable population of individuals, and thus can serve as a good reference to unravel specific features of human evolution.
Owing to their ability to reproduce specific features of human diseases at diverse levels, from molecules to tissues and organs, animal models have been increasingly used to gain understanding of the pathogenesis of several autoimmune diseases.
Larina, O. N. & Becker, A. M. Study of blood protein levels regulation of specific features for modeling the effects of microgravity on humans.
What are the mechanisms underlying the emergence of specific features in the human cortex?
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