Exact(4)
It also highlights study practices and procedures that can detract from the appropriate evaluation of human relevance of results, indicating the importance of adherence to international consensus protocols, such as those detailed by OECD.
Similarly, the epidemiologic data are inadequate to inform conclusions of human relevance.
The possibility of synergism may be of human relevance as inorganic lead and BaP are ubiquitous environmental pollutants.
The default assumption under that framework is of human relevance, unless there is evidence of toxicodynamic or toxicokinetic differences between the animal test species and humans that shows that the effect seen in animals is not expected to occur in humans.
Similar(56)
Here, the authors conflate the statistical impossibility of demonstrating the absence of effects (and thresholds) with the issue of demonstrating human relevance of toxicity data derived from testing on animals.
In addition, alternative, innovative methods may be required to estimate the full health impacts involving chemicals at population level, using for example a combination of disease trends, exposure patterns, biomarkers, and an improved understanding of the human relevance of effects seen in chemical testing systems.
Since appetitions are tendencies or strivings, ones which profoundly influence human actions, it is of distinct human relevance whether or not an individual human is conscious of all of these strivings.
The European Teratology Society and Health and Environmental Sciences Institute co-organized a workshop to consider best practices, including data quality and consistency, interpretation of developmental effects in the presence of maternal toxicity, human relevance of animal data, and limits of chemical classes.
A threat not to biodiversity itself but to increasing the knowledge of it is a continuing downturn in training of taxonomists, a problem that is particularly acute for taxa not of direct human relevance.
LA was chosen for this study because of its human relevance; however, future studies are needed to assess the effects of longer fibers in the SHHF rat.
In Part IV, the reader is introduced to a specific framework for analyzing mode of action and human relevance of chemical-induced tumors.
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