Sentence examples for of human administration from inspiring English sources

In acute toxicity studies, a single large or potentially toxic dose of the drug is administered to animals via the intended route of human administration, and the animals are observed for one to four weeks, depending on the drug.

Therefore, iv injection was selected to model the intended route of human administration.

Limited evidence from the human administration of EC has shown that it can in fact cause liver disease, specifically hepatic angiosarcoma [ 14].

Moreover, etanercept (a hybrid molecule consisting of TNFRII linked to the Fc domain of human IgG1) administration in nine subjects with IPF demonstrated tolerability, with functional improvement in some [75].

To that end, we report the early effects of short-term (16 20 weeks) metreleptin (an analog of human leptin) administration on β-cell function in patients with lipodystrophy.

Despite the many theoretical benefits of human albumin administration in critically ill patients, there has been little evidence to support its widespread clinical use.

In the long run, our goal is to achieve 90% to 100% protection of humans by administration of the fewest numbers of doses of an attenuated PfSPZ vaccine containing the lowest numbers of sporozoites.

In other animal species and humans, administration of antimicrobial drugs is considered a predisposing factor for development of CDAD (3, 7, 35, 36 ).

Importantly, first-in-human administration of ABT-199 to three patients with refractory CLL triggered a rapid antileukemic response, while largely sparing platelets from damage.

In humans, administration of the less active 1-α-hydroxyvitamin D3 in infancy was reported to reduce type 1 diabetes risk (3, 4, 20).

In animal models and in humans, administration of guggulipid is reported to significantly lower both serum LDL cholesterol and triglyceride levels [ 87- 89].