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In both studies, the combination arm produced increased response rates but at the expense of higher toxicity.
These studies support our assumption of higher toxicity of PtAcD toward cancer cell previously observed in immortalized breast cell lines.
Overall, the benefits resulting from the estramustine phosphate plus docetaxel treatment came at the cost of higher toxicity.
Rather than the higher toxicity being contributed by treatment interruptions, it was precisely because of higher toxicity that there were treatment interruptions.
Clinicians at our institute had often reduced the dose of cyclophosphamide, as commented on previously, in anticipation of higher toxicity in older women.
Combination therapy might promote synergistic effects leading to low drug dosage, as well as suppresses resistance to therapy if multiple cell survival pathways are targeted at once though there are chances of higher toxicity.
Similar(49)
Because of high toxicity of Se and its compounds, Se is detrimental to plants and animals [9].
It is an element of high toxicity, quite harmful to plant growth.
Most TPs generated were classified as of high toxicity (Cramer rules) and showed ready biodegradability (START biodegradability).
Processes based on the simultaneous use of ozone and activated carbon have proven very effective for removing contaminants of high toxicity and low biodegradability.
To approach the Be/H2 explosion problem, Be dust is substituted in this study by aluminium, because of high toxicity of Be dusts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com