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Common variation accounts for only a modest fraction of the predicted heritability and the role of rare genetic variation of higher effects (ie, odds ratios markedly deviating from 1) is increasingly being identified through sequencing efforts.
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The replicable findings of high effect across two cohorts give strong support to this developmental mechanism.
The phenotype of these traits is generally associated to many genes of small effect according to the infinitesimal model [ 2], but also to few genes of high effect.
Along the same line, we expect a diminishing return of mutation effect in the Early populations and conversely mutations of high effect in the Late populations [ 63, 64].
Similar findings of a higher effect of non-HDL HDL thanon-HDL HDLsthanLDLn risk of fatal/nonfatal cholesterolcently been reponted in thriskpreviofs observational studies.
The cause of the higher effect of bakhour on children from Sharqiyah region is not clear.
91 The higher contribution of non-specific effects in surgical trials could well be the result of higher placebo effects.
Their study showed some indication of a higher effect for conduction disorders, a slightly higher effect in females, and a higher effect with increasing age group.
The difference between the two indices provides an estimate of higher order effects of parameter perturbations in which particular combinations of parameters significantly affect AP-1 activity.
These SNPs include common variants with some of the highest effects on diabetes risk reported to date [ 19- 21].
Activation of ERK and p38 pathways might be the mechanism of higher cytotoxic effect of ATO-Indo combination.
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CEO of Professional Science Editing for Scientists @ prosciediting.com