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The relevance of high burden infection to TB disease in vivo was demonstrated by acid fast staining of lung leukocytes harvested from mice 2 wk after aerosol infection with 100 CFU Erdman delivered to the lung (Fig. S2).
To evaluate the relevance of high burden in vitro infections to events occurring in TB disease in vivo, C57BL/6 mice were infected with Mtb Erdman by aerosol (Glas-Col) set to deliver 100 CFU to the lung.
Our findings of high burden in older children and adults are highly relevant for vaccination strategies, particularly with pneumococcal, Hib, measles and pertussis vaccines.
The NTPs of high burden TB countries where a private sector is also present face difficulties in implementing treatment guidelines, resulting in inadequate treatment or non-compliance.
The countries are colour-coded to highlight areas of high burden of disease attributable to HAP from solid fuels as per Lim et.al. 5].
A combination of high burden of disease and large population reached makes KwaZulu-Natal the greatest beneficiary in terms of burden of disease averted.
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We hypothesized that S. aureus appears in the urine in bacteremic patients because of higher burden of organisms and thus may portend worse outcome.
However, several items of the BCHV revealed areas of higher burden that need to be addressed in the future to prevent further attrition of community volunteers.
While the association of higher burden with patient's youth has much support in the literature [ 11, 17, 21, 25, 26], the finding that higher burden was experienced by those caring for female patients is uncommon [ 23].
WHO reported that the number of high-burden countries, in which at least 4,000 new cases of drug-resistant disease arose annually or in which one-tenth of the total number of new cases were drug resistant, reached 27 in 2009.
Thirty-eight patients across both cohorts showed a morphological CR and MRD-CR rate of 61% and 53%, 13/16 (81%) of low-burden patients had a morphological CR, while 10/22 (45%) of high-burden patients attained a morphological CR.
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