Sentence examples for of heart development from inspiring English sources

The importance of RA signalling in early stages of heart development is supported by studies in mice where embryos lacking RA receptor RXRα developed SHF defects (Ryckebusch et al., 2008) and absence of Raldh2 resulted in delayed epicardium formation (Jenkins et al., 2005).

This review discusses RBPs in the context of heart development.

The differentiation to cardiomyocytes is a prerequisite and an important part of heart development.

Decades of progress in developmental cardiology has advanced our understanding of the early aspects of heart development, including cardiomyocyte (CM) differentiation.

Existing studies of heart development have identified a role for fluid forces in specifying the internal form of the heart (Hove et al. 2003) and its left/right asymmetry (Nonaka et al. 2002).

Here, we give an overview of heart development and function in the fish and highlight a number of areas where it is most actively contributing to the understanding of cardiac development and disease.

In this work we have engineered a new Nkx2-5 conditional knockout mouse in which flox sites flank the entire Nkx2-5 locus, and validated this line for the study of heart development, differentiation and disease using a full deletion strategy.

Since the targets and functions of most RBPs — in the heart and at large — are not fully understood, this review focuses on the expression and roles of RBPs that have been implicated in specific stages of heart development or developmental pathology.

These may represent gene models that are more prominently expressed during later stages of heart development.

Interestingly, both bmp4 and versican are restricted to atrioventricular boundary of heart at the later stage of heart development [27].

The etiology of this defect was analyzed by examining Hes1−/− embryos at earlier stages of heart development.