Sentence examples for of genotoxic damage from inspiring English sources

In cell lines, the induction of p53 expression in response to treatments with DNA-damaging agents has been proposed as a tool for the detection of genotoxic damage, although a direct correlation between a marker of chromosomal damage and p53 expression has not previously been studied.

To link ROS increase with adult cardiac progenitor differentiation, we tested several types of genotoxic damage.

In addition, we found that several types of genotoxic damage increased the contribution of Bmi1-derived progenitors to mature cardiac progeny, and that this ROS-mediated differentiation effect was partially rescued by antioxidant treatment.

Toward this overall goal, the objectives of this study were to examine the effect of the localized microenvironment of cells, cultured as either 2-dimensional (2D) monolayers or 3-dimensional (3D) aggregates, on the rate and type of genotoxic damage resulting from exposure to Fe-charged particles, a significant portion of space radiation.

Thus, cellular senescence is an early response upon stress and among the biological consequences of genotoxic damage to cells in vivo.

The results of this investigation suggest that water extracts of LD are toxic to cancer cells in vitro, triggering apoptosis possibly as a result of inducing some form of genotoxic damage.

Recent studies also revealed a higher incidence of genotoxic damages in traffic police and populations exposed to moderate levels of PAHs in urban areas (Kyrtopoulos et al. 2001; Maffei et al. 2005).

In this way, the clonality of the breast epithelium may, in part, account for the enhanced sensitivity of the breast to genotoxic damage as a mechanism of carcinogenesis.

As a critical cellular mediator of the response to genotoxic damage, P53 has a direct role in maintaining the integrity of the genome.

Cigarette smoking is thought to contribute to carcinogenesis by formation of DNA adducts of tobacco smoke constituents leading to genotoxic damage.

While a core set of genes is regulated in the same direction after both types of damage, the response to genotoxic damage is generally more robust than the response to RAG-induced breaks.