The changes we observe may represent the operation of a general processing strategy through which the brain stores information from previous experience in ventral circuits to reduce the need for dynamic processing by the dorsal stream.
It may be argued, that the effects reported in the present study may not be specific to processing the meaning of music or language, but results from the more general processing of emotional valence.
In contrast, activity in the anterior temporal lobe appears to reflect general processing of acoustic scale.
The design and general processing of P. pastoris microarrays used in this study was described in ref. [ 12].
It could therefore be that the changes in acoustic scale in our previous studies (unpublished data) activate regions implicated in general processing of the spectral envelope.
The finding seems to support a general processing of item-feature associations for source encoding in the parahippocampal cortex [ 13, 53].
This pattern of development change in amplitudes and latencies was common across all stimulus types within each modality, and thus likely represents changes in the general processing of auditory and visual information in the brain.
As Nol9 depletion specifically blocks generation of only the 5.8S and 28S rRNA, but does not impair 18S maturation or RNA methylation as observed with metabolic labelling, it is unlikely that Nol9 is involved in the general processing of snoRNAs.
Moreover, the demonstration that the shell-lesioned animals were unimpaired on the object-familiarity discrimination in Experiment 1 and preferentially explored the novel object at test indicates a role beyond the general processing of novelty.
For example, there is often a slowing of reaction time on the go trials, as indicated by increases in the mRT, as well as on the stop-trials, which may be indicative of a general processing-speed impairment rather than a specific inhibitory deficit (Oosterlaan, Logan, & Sergeant, 1998; Overtoom et al., 2002; Tannock, 1998).
