This and other polymorphisms if proven to be of functional significance could represent potentially significant candidate genes in the regulation of tumour angiogenesis.
In addition, significant interspecies differences in AR amino acid sequences may be of functional significance.
"A major next step will be to find out not only what the unique human genes are doing, but whether the genes we've got from Neanderthals are of functional significance.
The resulting complete Med-PIC structure reveals two components of functional significance, absent from previous structures, a protein kinase complex and the Mediator-activator interaction region.
This binding is of functional significance because myocytes exhibit diminished norepinephrine-stimulated hypertrophy when expressing a mAKAPβ mutant incapable of binding calcineurin.
Of functional significance, hMena/hMena11a knock-down reduced the mitogenic activity of EGF and NRG1.
We decided to further investigate whether this was of functional significance.
FDR controlled p-values (FDR<0.05) were used for the assessment of functional significance.
These changes had little effect on perfringolysin O activity (Table 2), implying that these residues were not of functional significance.
This neuroanatomical circuitry revealed in the mouse in the current study is likely to be of functional significance.
Since FragKB contains literature derived fragment annotation, it enables interpretation of functional significance of a specific conserved fragment.
