Exact(10)
The origin of functional innovation is among the key questions in biology.
A powerful source of functional innovation is gene duplication and loss [ 14].
Gene duplication provides raw material for the evolution of functional innovation.
One important mechanism of functional innovation involves changes in gene expression [ 1] caused by cis-regulatory mutations [ 2].
Duplogs, or intraspecies paralogs, constitute the important portion of eukaryote genomes and serve as a major source of functional innovation.
Genome-wide functional analysis of duplicate genes is in attempt to reveal functional correlation between genetic and epigenetic factors during the process of functional innovation through gene duplication.
Similar(50)
However the determination of the target and precise role of each PTP is needed for a detailed understanding of the role of functional innovations in bracovirus PTP evolution.
The work resolves alternative hypotheses for the homologies of the ascidian atrial siphon, illuminates evolution of the thyroid, identifies candidates for ancestral gene subfunctions, and defines the origin of functional innovations in this gene family.
Mutations may be better buffered in the case of multicopy genes, which may be maintained after duplication principally due to gene dosage constraints rather than because of functional innovations (Aury et al. 2006).
Gene duplication is a major source of genetic material for functional innovation in evolution, leading to a high genomic abundance of duplicate genes [ 6– 8].
Gene duplication is generally accepted as a very important source of raw material for functional innovation [ 33- 36].
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