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However, the description of existing recommendations was made in only one quarter of the cases.
Interestingly, US FDA's guidance does not issue new regulations, but is an interpretation of existing recommendations on drug development.
We acknowledge the large body of previous research that links interpregnancy interval with adverse birth outcomes and the importance of existing recommendations on spacing between births.
Our observations support the importance of existing recommendations for control of transmission of influenza infection in HSCT recipients during an influenza pandemic (22 ).
In the absence of existing recommendations for decision-making on the acceptability of carrying forward pilot data into the full trial dataset of pragmatic trials, we wanted to develop a method of recording design modifications made during the pilot phase.
Here a major reason given for strongly rejecting what was already being practiced, in support of existing recommendations, was the perceived need to preserve the alternative treatments as second line regimens in the absence of viable alternatives.
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In this paper, we propose a method to expand the repertoire of existing recommendation evaluation techniques with a method to evaluate the discoverability and navigability of recommendation algorithms.
Taking advantage of existing recommendation system techniques, the proposed architecture goes beyond the state of the art by making use of a commercial cloud computing platform to provide scalability, reduce costs and, more importantly, response times.
The application of established techniques from network science allows us to present a novel method that extends common evaluation measures towards a path-based evaluation and expands the arsenal of existing recommendation evaluation techniques with two dimensions that have not received sufficient attention so far.
Moreover, users of guidelines need to be confident that they can rely on existing recommendations.
Findings from this study will contribute to the cost-effective evidence based management of hand OA and to existing recommendations published by EULAR.
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CEO of Professional Science Editing for Scientists @ prosciediting.com