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Instead it offers a detailed catalogue of existing discoveries, especially during this century, and then draws particular attention to the points where this edifice displays gaps or tensions.In this section What the world is reading Like and unlike Beware of bears A first world war Everybody digs?
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Putting existing discoveries into this framework helps answer our questions.
This work contributes to better understanding of failure behavior in existing discovery systems, allowing potential users to configure deployments to obtain the best achievable robustness at the least available cost.
Perhaps existing discovery methods, including earlier deep sequencing approaches, were not sufficiently sensitive to detect low concentrations of these microRNAs.
To generate a motif discovery tool, the effectiveness of existing motif discovery tools was first analyzed using benchmark data sets containing known motifs from Sandve et al. (2007).
In this article we present our views on how the outsourcing model in drug discovery should go beyond increasing the efficiency of existing drug discovery processes to a fundamental rethink and re-engineering of these processes.
We evaluate DREME and compare it with a number of existing motif discovery algorithms using several TF ChIP-seq datasets from mouse embryonic stem cells (mES cells), mouse erythrocytes and a human lymphoblastoid cell line.
Modest treatment outcomes of approximately 65% of cases responding suggest that aetiological and clinical heterogeneity may hamper the better use of existing therapies and discovery of more effective treatments.
The other two, however, are more about discovery of existing literature rather than creating new things.
Jonathan Eisen, a researcher at UC-Davis who is not working on the project, says that although that might not produce new kinds of fuels, these undiscovered species could make the discovery of existing fuels more efficient.
After 50 years of no antituberculosis drug development, a promising pipeline is emerging through the repurposing of old drugs, re-engineering of existing antibacterial compounds, and discovery of new compounds.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com