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Thus, insights from research within the Dutch context, which has specific challenges for both categories of youngsters, will be used as prime examples of existent knowledge.
Trialists and research ethics committees should verify a state of reasoned uncertainty in relation to an up-to-date synthesis and appraisal of existent knowledge and the informed beliefs of colleagues.
Previous work has shown dissonance between the opinions of experts and the state of existent knowledge as revealed by a systematic review or meta-analysis of the relevant literature.[ 10] The factors in Panel 1 applicable to the proposed trial should be addressed in relation to a systematic review.
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Importantly, a big part of the critical findings of mechanisms of effects of ABx was revealed using network analysis and could not be predicted based on existent knowledge in the field.
Finally, as Chalmers has described, an up-to-date systematic review will also be of substantial value in two other important ways: to enhance interim results monitoring of an ongoing trial, and to facilitate the informative reporting of a trial's results in relation to existent knowledge.[ 13] The state of knowledge concerning treatment effects changes as evidence is cumulated and synthesized.
Congress may not authorize the issuance of patents whose effects are to remove existent knowledge from the public domain, or to restrict free access to materials already available". Graham, 383 U. S., at 5-6 (emphaddedadded).
The conduct of clinical research should be informed by existent knowledge.
The first factor – existent knowledge concerning the relative efficacy of the proposed experimental and control interventions – is a principal focus of the ensuing discussion.
These gaps in the existent knowledge have limited the research on otoprotective strategies mainly to prevention and to an empirical matter of trial and error.
Blunt later admitted she had a "non-existent knowledge" of the queen, but after consulting her mother about Victoria's successful marriage, Blunt told King that the queen "was a young girl who was very in love for the first time, and she was in a job where she felt way over her head.
So we do not need to worry about an overpopulation of existent beings, as existent beings exemplify existence, which the existent winged horse does not.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com