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Cross-species analyses showed that the evolutionary conservation of genes and the presence of essential orthologues are each strong predictors of essentiality in eukaryotes.
Our definition of essentiality implies that a given gene is essential if it has an essential function, which is conserved across other members in its close ecological niche.
We then compared the frequency of essentiality for C. elegans genes that grouped with essential or non-essential S. cerevisiae orthologues.
Here we use the usual definition of essentiality, i.e., a gene is essential if its single-perturbation is lethal.
Sets of genes with correlated patterns of essentiality across the lines reveal new gene relationships, the essential substrates of enzymes, and the molecular functions of uncharacterized proteins.
We therefore expected that gene size may be indicative of essentiality, especially in E. coli, as ancestral genes are likely essential.
It was accompanied by a certificate of essentiality, issued by the Electricity Commissioners.
Numerous characterization studies of these minimal genomes in terms of essentiality have been performed [3], [6], [30], [31], [33], [34].
This finding is consistent with the results of Yu et al. [28] that PPI degree is a better predictor of essentiality than BW.
Protein size was predictive of essentiality in both organisms.
Large DRA-divergence is thus a strong indicator of essentiality.
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