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KRAS mutations are among the most common oncogenic events in human carcinomas of endodermal origin, whose presence predicts for resistance to several target therapies.
A new study shows that Sox9 marks a putative adult stem cell population that contributes to the self-renewal and repair of the liver, exocrine pancreas and intestine, three organs of endodermal origin.
In bladder, another organ of endodermal origin, we find that despite its initial presence in the cancer cell of origin Sonic hedgehog (Shh) expression is invariably lost during progression to invasive urothelial carcinoma.
Indeed, it seems that some of the lateral root primordial cells originating from the endodermis generate a "tasche," a temporary structure that is later replaced by a new root cap, although some cells of endodermal origin will form the lateral root epidermis.
Prostate epithelia are of endodermal origin [12].
Here we set out to test the importance of the NMD component UPF2 in a tissue of endodermal origin.
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The gastro-vascular system, of mainly endodermal origin, opens at one extremity by the mouth and at the other by two anal pores.
Protocols with EBs yield a small fraction of neural lineage cells due to the presence of cells of mesodermal or endodermal origin.
A role for p63 has been established in cancer types of ectodermal or endodermal origin, in particular lung and skin carcinomas.
Arsenic can disrupt the highly complex signaling between embryonic lung tissues of mesenchymal and endodermal origin and can permanently alter lung structure and function when exposure occurs at key developmental windows.
○ ** MedDRA tends to use "carcinoma" as a synonym for malignancy/cancer, whereas the term strictly refers to a malignancy of ectodermal or endodermal origin, as opposed to a "sarcoma" that derives from mesoderm.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com