Sentence examples for of either residues from inspiring English sources

Very pragmatically the protonation states of functional groups of either residues or candidate ligands are set to standard values.

N-terminal constructs consisting of either residues 1−917 (including the polymerase core and the HhH motifs) or 1−835 (lacking the tandem HhH motifs) showed no evidence of binding to ssDNA, as complete DNA reannealing occurs at high forces (∼40 pN) upon relaxation.

Deletion of either residue does not block cleavage, however deletion of S192,F193 (ΔSF) or F193,L194 (ΔFL) blocked cleavage at these sites.

Importantly, the charge of this monovalent cationic drug remained complemented by the unsubstituted carboxylate of either E90 or E120, with the alanine or glutamine substitution of either residue having little impact on binding affinity or induction capabilities of MG (Tables 1 and 2).

Mutation of either residue therefore prevents GTP hydrolysis.

Mutagenesis of either residue to glutamate resulted in a nonfunctional receptor.

Phosphorylation of either residue weakens the affinity of CaMKII for Ca2+/CaM (Hanson and Schulman, 1992; Colbran, 1993).

Supporting this hypothesis is the fact that mutation of either residue leads to almost complete inhibition of the PHLPP2 activity, even though the mutants are normally expressed.

Furthermore, mutation of either residue significantly decreases the affinity of gyrase or topoisomerase IV for quinolones, and mutation of both residues abolishes the ability of clinically relevant quinolones to stabilize cleavage complexes.

Besides the OH-cluster, two residues, C128 and D156 (DC-pair in Fig 2) are of fundamental importance for both channel opening and closing, and mutation of either residue results in a dramatic increase of the open state(s)' lifetime.

We observed sizable changes in the preference for helix azimuthal rotation when a key aromatic ring, the side chain of either residue 5 or residue 19, has been moved by 100° around the helix axis (Tables 3 and 4).