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Each reaction included 2,000 beads of each specificity.
Representatives of each specificity class have been studied at molecular and genetic levels.
Very likely, old specificities are replaced by the newly evolved specificities, due to the small effective population size of each specificity.
However, the relative abundance of each specificity is modulated by the individual's history of antigen exposure, as antigen-driven selection in the periphery leads to differential expansion of specific TCR clonotypes.
The SSc sera we tested were not randomly selected, however, the proportion of each specificity is not far from a randomly selected SSc cohort, and it should give us a reasonable idea of the specificity of the assay in general SSc patients.
Similar(55)
In all cases, the number of genes in each specificity category increased in the co-assemblies, although the percentages remained similar.
For linear activation, deriving expressions for each of the specificity indicators has been done previously [ 25].
Fortunately the exact formula for each of the specificity indicators can be derived straightforwardly.
Our target through combining search terms was to optimize each of sensitivity, specificity, and accuracy.
Rather, the contribution of each is its specificity.
Because the same compounds can often be classified into multiple categories, an analysis of the specificity of each categorical term was performed.
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