This helps avoiding rewiring of simulation models on each engagement.
The members of this large receptor gene family couple to primary effectors, G proteins, that have built in mechanisms for regeneration and amplification of signaling with each engagement of receptor and ligand, a kinetic event in itself.
But hiring older managers with a string of failures on their resumes and lots of excuses about why each engagement didn't work out is also fraught with risk.
Alternatively, each engagement of pMHC with TCR (serial triggering; Valitutti et al., 1995), perhaps with some minimum engagement time (kinetic proof reading; McKeithan, 1995; Rabinowitz et al., 1996), might define the threshold for TCR triggering.
Furthermore, we applied principles of Hierarchical Information Integration by identifying six separate research engagement actions (e.g., searching, appraising, generating research), identifying the key, non-overlapping subactions of each research engagement action, and undertaking a separate choice experiment for each action [ 61, 62].
A vast number of examples of each research engagement action were identified.
Consequently, they can provide informed and context-sensitive judgments regarding the relative importance of each research engagement subaction.
We undertook a comprehensive, step-by-step approach to identify the subactions of each research engagement action.
Having identified the subactions of each research engagement action, the next step involved dividing each subaction into its 'levels' (Table 1).
The conjoint analysis will allow identification of which subactions experts consider to be better or worse examples of each research engagement action by calculating numerical weights (called utilities) for each subaction.
