Some compounds, such as moxifloxacin and rifampin, confound the prediction of dual activity based on ratios of ∼0.25 to 0.5.
In addition to showing equal potency against wild-type and multidrug resistant HIV-1, the AZT CSA conjugate displayed significant contraceptive activity in an animal model, providing the initial proof-of-concept for the design and synthesis of dual-activity compounds based on these combinations.
Here we show that a complex analysis of differentially expressed genes in lens compared to four related telencephalic samples provide evidence for dual activities of Pax6 both to promote and suppress mutually exclusive developmental programs, during lens and forebrain development.
As detailed below, the author's definitions of Yin (tumoricidal) and Yang (tumorigenic) properties of effective immunity may serve larger applications for understanding of the biphasic (dual) activities of system biology in sustenance of health or initiation of diseases [4 8].
When examining the regulation of the cytoplasmic domain of PSKR1 in vitro, it was previously found that the kinase activity was inhibited by cGMP [ 6], suggesting the potential for bimodal modification of the dual activities.
The present study aims to evaluate the validity of an alternative simplified approach in the design of cancer-targeting nanotherapeutics: conjugating a single type of molecule with dual activities to nanoparticles, instead of coupling a pair of orthogonal molecules.
While effective, designing and developing a bioassay strategy for dual specific antibodies that is reflective of the mechanism of action (MoA) and also measures the dual activities of antibodies pose unique and exciting challenges.
Structural and functional analyses of 18 mutants revealed two independent binding sites corresponding to the dual activities of HWTX-XI: strong inhibition of serine proteases and weak inhibition of Kv channels.
Therefore, uncovering of the biochemical function of Hd1 protein and the molecular nature of its dual activity will provide exciting insight into the control of photoperiodic flowering in rice.
Notch signalling attracted our attention because of its dual activity as potent inhibitor of neural differentiation and regulator of GBM stem cell phenotype and aggressive behaviour.
