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In situ phenotyping of tumor biomarker expression and karyotyping of chromosome ploidy performed by iFISH® will shed light on additional intriguing clinical utilities and significance of diverse subtypes of CTC/DTC, and will also help guide more meaningful studies performed on the targeted single tumor cell enriched from different types of cancer patient or tumor animal models.
Such glycospheres were used to selectively capture influenza virus of diverse subtypes from a variety of samples.
Src is highly expressed and activated in sarcomas of diverse subtypes, including high-grade osteosarcoma, leiomyosarcoma, synovial sarcoma and liposarcoma [ 34, 40].
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Induction of HIV-1-specific T-cell responses relevant to diverse subtypes is a major goal of HIV vaccine development.
Since the pathological examination of claudin-low tumors identified special histological features, we applied the nine-cell line claudin-low predictor to a publicly available database of histologically diverse subtypes of breast cancer (n = 113, NKI113) [ 14], which includes 10 medullary carcinomas, 20 metaplastic carcinomas and 22 invasive lobular carcinomas (ILC).
Alternative splicing of the slo mRNA [27] as well as tissue-specific β subunits are found to give rise to diverse subtypes [38].
This widened diagnostic spectrum has revealed deeper insights into disease-specific chromosomal and molecular alterations in acute leukaemias and has also led to improved understanding of the genetic heterogeneity of the diverse subtypes.
They enabled milestone discoveries in pharmacology and biochemistry ranging from the original formulation of the receptor concept, the first isolation and structural analysis of a receptor protein (the nAChR) to the identification, localization, and differentiation of its diverse subtypes and their validation as a target for therapeutic intervention.
We selected two of the best compounds 45A (NBD-14009) and 46A (NBD-14010) to test against a panel of 51 Env-pseudotyped HIV-1 representing diverse subtypes of clinical isolates.
Recently, Simmons et al. [20] characterized diverse subtypes of trophoblast giant cells (TGC) based on expression of specific markers, including Pl-I, Pl-II, Plf, and Ctsq, and showed that formation of these subtypes by TS cells is differentially regulated in vitro.
In LPMs, diverse subtypes of AIVs are brought together by various types of poultry from many regions, which might facilitate the emergence and spread of new reassortants.
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