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Twelve organic water pollutants of diverse structure and unique known modes of action were studied individually and as mixtures mirroring exposure scenarios in freshwaters.
Scaffolds of diverse structure, flexibility, and valency are gaining increasing biomedical importance in the development of artificial multivalent ligands for these interfaces.
We have identified from ligands of diverse structure, several particularly interesting ones that are high potency selective agonists via ERα and others that are full agonists through ERα while being full antagonists through ERβ.
The results presented here indicate that C181 and C184 of H-Ras can be targeted by several bifunctional molecules of diverse structure, such as PAO and DBB.
Moreover, the activity-specific PSSM libraries also accurately identify homologous functions in proteins of diverse structure, as well as differentiate the activity within a specific fold.
Unlike ordinary MDR, it can identify single‐locus effects or joint effects of multiple loci in families of diverse structure.
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Its main use is to find representative subsets from high throughput screening (HTS) [4]-[6], to design chemical libraries of diverse structures pertinent to pharmaceutical discovery [7]-[9] and to increase the diversity of these libraries through the selection of additional compounds from other data sets [10],[10].
A recent review by Thiambi Netshiluvhi of South Africa's Department of Science and Technology found "inadequate capacity" and "poor use of diverse structures" for scientific advice in a majority of African countries.
The cells of the neural crest migrate to numerous locations in the body and contribute to the formation of diverse structures, mostly associated with the nervous system.
Several photocatalysts with different architectures were synthesized via a facile hydrothermal approach in the presence of diverse structure-directing reagents at varied concentrations.
These methods are particularly useful for compounds of diverse structures to complement QSAR methods, and for cases of unavailable receptor 3D structure to complement structure‐based methods.
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