It is prone to high rates of genetic mutation, resulting in evolution to divergent forms and six major genotypes [ 1].
An unexpected finding from the transcriptomic analysis of developing bitter melon seeds was the discovery of two divergent forms of FAD2, the Δ12 oleic acid desaturase.
One of the two divergent forms of leucyl-tRNA synthetase in haloarchaea was acquired from an organism related to the ancestor of the bacterial domain by an ancient transfer (Andam et al. 2012).
Further, the importance of having two divergent forms of GroEL for protein folding is suggested from observations on GroEL sequences in Synechocystis sp. PCC 6803, where it has been observed that GroEL1 and GroEL2 respond differently to heat shock and light conditions [ 20, 21].
The similarity of plasticity mechanisms across divergent forms of CNS injury suggests that plasticity, as with development, uses a limited repertoire of events across numerous contexts.
Even though environmental divergent sequences showed no match to known viral sequences, the possibility that some of these environmental divergent forms are carried by viruses rather than hosted in cells remains of course open.
This "missing" aspect provides a reasoned explanation for what has, and is being, increasingly reported in the mainstream literature – that inflammatory and immune responses appear intricately associated with, if not causative of, complete responses induced by divergent forms of cancer therapy.
6– 13 The present authors' reasoning for a "final common pathway" through the human inflammatory and immune system offers a quite valid explanation for the observations over time for the random, consistently low number of therapeutic successes from multiple, very seemingly divergent, forms of cancer therapies.
In heterothallic (obligate outbreeding) species, these MAT genes are contained within a region of the genome termed the MAT locus, with highly divergent forms of this locus, known as "idiomorphs," present in isolates of sexually compatible MAT1-1 and MAT1-2 genotypes.
Over 50 years of cancer therapy history reveals complete clinical responses (CRs) from remarkably divergent forms of therapies (eg, chemotherapy, radiotherapy, surgery, vaccines, autologous cell transfers, cytokines, monoclonal antibodies) for advanced solid malignancies occur with an approximately similar frequency of 5%10%%.
