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The chromatin-remodeling protein Satb2 plays a role in the generation of distinct subtypes of neocortical pyramidal neurons.
The marked behavioral heterogeneity evident among adolescents with MDD suggests the possibility of distinct subtypes.
Through a groundbreaking series of studies, Jessell revealed how naïve neural cells develop into hundreds of distinct subtypes of motor neurons to form that remarkable circuitry.
This study shows that modular synergism between miRNAs and neuronal subtype-specific transcription factors can drive lineage-specific neuronal reprogramming, providing a general platform for high-efficiency generation of distinct subtypes of human neurons.
To characterize the optical coherence tomography (OCT) angiography, en face OCT, and microperimetry features of paracentral acute middle maculopathy in both the acute phase and after resolution, and to propose a classification of distinct subtypes of this entity.
Stem/progenitor cell aging involves not only alterations in the molecular characteristics of distinct subtypes of NSC/NPCs, but also changes in the cellular microenvironment, including blood supplies, content of cerebrospinal fluid, and interplays amongst not only NSC/NPCs but also surrounding cells.
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Molecular stratification of gene-expression data has defined a minimum of five distinct subtypes of breast cancer [ 1].
In addition, a better definition of mechanistically distinct subtypes of complex diseases will greatly enhance the power and value of the GWAS approach [ 56].
As with PET studies, these subtypes remained distinct over longitudinal follow-up, again supporting the idea of true distinct subtypes of disease [ 21].
This evidence supports the existence of two distinct subtypes of endometrioid EOC that may originate from different sources, (reviewed in [ 59]) based on differences in molecular pathobiology.
This work suggests that depression may not be a homogenous disorder characterized by a single phenotype, but a heterogeneous constellation of potentially distinct subtypes of symptom syndromes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com