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More broadly, CRISPR screens like the one in this study have been used to investigate a range of disease pathways.
However, with improved screening technology and better understanding of disease pathways, CRC is more likely to be detected at early stage and thus more likely to be cured.
Multiple biomarkers represent various elements of disease pathways.
The emergence of network medicine [ 1] has explored disease complexity through the systematic identification of disease pathways and modules.
In addition, we achieve a greater understanding of disease pathways, targets of interventions, and the pharmacologic consequences of medicines.
Conformational changes in proteins have been extensively studied with a particular focus on enzymes involved in a variety of disease pathways.
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Groop, P. H., Forsblom, C. & Thomas, M. C. Mechanisms of disease: pathway-selective insulin resistance and microvascular complications of diabetes.
Second, we related the targets and ligand clusters with the information of diseases, pathways and drug adverse reactions to facilitate the query of ligand clusters associated with certain disease, pathway and drug adverse reaction.
To estimate the background distribution of disease-pathway association, we adopted a randomization-based approach.
To estimate the background distribution of disease-pathway association, we randomized the disease genes and repeated the association process 1000 times (Materials & Methods).
In this review, we distinguish and evaluate two principal pathways by which GBHs may affect the susceptibility of crops to disease: pathway 1 via disruptions to rhizosphere microbial ecology, and pathway 2 via restriction of nutrients to crops.
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