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This early onset deficit may relate to the degree of difficulty required to perform accurately in a task that maximizes both spatial information processing and flexible working memory representations.
This is achieved by estimating the learner's current knowledge in a discrete model of this problem space, and by using this representation to present the learner with problems at the level of difficulty required to maintain the desired success rate.
Secondly, the focus on capturing the level of difficulty required to complete a task, rather than frequency of impairment, has the potential to provide more meaningful measurement of behaviour and functioning.
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Retrospectively, the Famicom version of Final Fantasy III is considered a typical RPG of its day, with a high degree of difficulty requiring a significant amount of grinding.
However, when the four questionnaires in this study were compared directly with each other, all seemed to be similarly sensitive to the presence or absence of some form of difficulty requiring referral.
Twin, recurrence risk, and prospective tracking studies have not only improved our understanding of the etiology of neurodevelopmental conditions but also bolstered our capacity to identify children at risk of particular conditions in order to effectively intervene before the emergence of stable and severe levels of difficulty requires costly remediation.
All the team leaders would have telephone contact with the Nepali researchers in case of difficulties requiring action.
Patients experiencing worsening of symptoms of urinary difficulty require surgical intervention with transurethral resection of the prostate (TURP) (Table 5).
The assessment of voiding difficulty requires the control of several confounders: hydration status, administration of agents during GA [ 9].
Understanding this difficulty requires an appreciation of how Notch is activated: binding of DLL1 or Jag1 ligands to the Notch extra-cellular domain triggers a conformational change that exposes a β-strand of Notch to cleavage by ADAM family metalloproteases [41], [42].
It escapes its period with difficulty, requiring the kind of treatment it received on Wednesday.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com