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"A lot of different fates could have come to this stone.
The acquisition of different fates by cells that are initially in the same state is central to development.
Lineage tracing experiments have shown that ISCs, rather than dividing asymmetrically to generate daughter cells of different fates, divide symmetrically and adopt stem or transit-amplifying fates in a stochastic manner [162,163].
Our results are in agreement with previous studies on HIV gene expression, where it was shown that the existence of different fates for infected cells correlated with the virus-integration sites [ 16, 50], and that transcriptional burst size and burst frequency vary depending on the virus-integration sites [ 38, 39].
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In general, however, when a division results in two cells of different fate, it is the daughter that is more to the outside that contributes to the TE, whereas the more inside daughter forms the ICM.
Figure 1 Sources of carbon emissions and types of carbon stabilization for different fates of harvested biomass following a forest fuel reduction treatment.
Increased or decreased YAP activity reprograms subsets of hepatocytes to different fates associated with deregulation of the HNF4A, CTNNB1, and E2F transcriptional programs that control hepatocyte quiescence and differentiation.
Such qualitative variabilities within the same cell population are generated by epigenetic commitment of cells to different fates (e.g., proliferation versus differentiation) as well as by genetic alterations (Fig. 1b) as in cancer [ 13, 14].
Lingering on the story of two young women, Putnam painted the picture of utterly different fates that had nothing to do with the merits of the young women, but everything to do with the education and prosperity of their parents.
This creates an opportunity for social interactions which are able to dynamically redistribute cell fates within a community and to directly share the benefits of the different fates.
In all cases, inactivation of LIT-1 led to both daughter cells having the same fate instead of two different fates, as occurs in WT embryos.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com