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And so it was thought that this was a very flexible ligand binding domain and that it could accommodate a number of different conformation.
The effect of different conformation of collagen on cell adhesion, morphology, proliferation, alkaline phosphatase activity and expression of three osteoblast-related genes were evaluated.
This may be due to the solvation and stability of different conformation in different solvent.
However, the field should be cautious about blocking the conversion of toxic oligomeric species to possible beneficial aggregates or shifting the balance of different conformation in an unfavorable direction [ 108].
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Evidence has accrued suggesting that topologically different conformers of 1,25-D3 1,25-D3d to proteins in different ways, including the induction of different conformayions of protein.
To obtain a large number of different conformations of bound cholesterol, only runs that resulted in an RMS difference >2 Å were considered.
The variance of the observed chemical shifts within the groups of different conformations is about 0.5 ppm and, therefore, comparable to the experimentally observed differences induced by sulfation.
The role of different conformations and their effect on photophysical properties is examined.
The latter can be achieved by applying rigid docking to a large number of different conformations of the receptor16, or by applying flexible docking approach to a single model24, 25.
It is suggested that Membrane Transporter functionality is based on low energy paths between proteins of different conformations.
However, our docking model was insufficient to specifically identify VDR antagonists and thus, further investigation using ensemble docking (i.e., combinatorial docking using diverse series of conformations for antagonists as well as a collection of different conformations for the VDR binding site) will be necessary to better account for the flexibility of the binding site.
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