Additional file 3: An example of the detailed quality control spreadsheet containing coverage gaps and exon level coverage details for each gene in the diagnostic target region of the analysis profile.
During a 2- week period in July 2010, registration personnel at the GPHC ED prospectively collected patient information as part of a detailed quality assurance database.
Instead of conducting a detailed quality appraisal of individual studies, we examined study methodology and generic study design limitations, including self-reported generic limitations, to construct a collective assessment of study quality.
As the specialist nature of research review is significantly different from most other activities of consumer representatives, detailed, quality training is essential.
The goal of the CPCTR is to collect large numbers of prostate cancer specimens with accurate quality controlled and standardized pathologic review of specimens and detailed, quality controlled outcome data for use in biomarker validation studies, and to make this collection available to the research community.
Moreover, due to the high sensitivity of modern analytical chemistry, detailed quality control and reduction of potential contamination with the analyte from other sources is needed (Calafat and Needham, 2007; Dekant and Völkel, 2008; Hoppin et al., 2006).
Table 2 shows the detailed quality of included individual trials.
A detailed quality of life assessment was made using daily diary cards.
Such a study should also take the opportunity to collate detailed quality of life data given that recurrent ovarian cancer is generally incurable.
The need for improved standardisation and validated end points of clinical trials for NETs has been recognised (Kulke et al, 2011) and the results of further studies should include a prospective detailed quality-of-life assessment, which can inform patients' treatment selection, determine resource allocation and influence healthcare policy (Ramage et al, 2011).
