We analysed the sensitivity of the descriptive estimates to inclusion and exclusion of these flagged submissions.
For descriptive estimates of the management rates of morbidity problems, the intra-cluster correlations ranged from 0.005 for estimates of eye problems to 0.059 for estimates of psychological problems, with design effects of between 1.5 and 6.8 respectively.
Descriptive estimates of costs by category and per intervention arm as well as per site (Toronto, Calgary) will be calculated.
First, descriptive estimates of key demographic and epidemiologic outcomes are presented using statistical summaries of means, proportions, and standard deviations around the means.
** Descriptive estimates of parasite reductions at 24 hours are provided only for comparisons with 12 hour estimates, see section 'Statistical analysis' *** Reference category is <5 years Time to clearance of parasitaemia for the different drugs are given in Figure 1.
For descriptive estimates of demographic variables the intra-cluster correlation ranged from 0.055 for sex of patient at encounter to 0.451 for language spoken by the patient at home.
** Descriptive estimates of parasite reductions at 24 hours are provided only for comparisons with 12 hour estimates, see section 'Statistical analysis' Mean PRR using either a single dose artesunate or single dose artemisinin was higher than parenteral artemisinins at 12 hours (65.9% for rectal treatment compared with 60.0% for parenteral treatment).
When analysing the association between holding a health care card and other demographic variables, the ICCs ranged from 0.012 for patient sex to 0.128 for language background (Table 3), which were smaller than for the descriptive estimate of the percentage holding a health care card (Table 2).
The second most frequently used items in PT tools were: reporting of withdrawals and dropouts, method of randomization concealment, description of inclusion/exclusion, reporting of descriptive measures for point estimates, blinding of therapist, and blinding of participants (71%, 5/7 tools).
Analysis will mainly consist of descriptive statistics and generalised estimating equations, including subgroup cluster analysis.
